Biased Signaling Atlas

metoprolol

Agent/drug
Bioactivity

metoprolol

SMILES	COCCc1ccc(OCC(O)CNC(C)C)cc1
InChIKey	IUBSYMUCCVWXPE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	9
Molecular weight (Da)	267.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Mouse	Adrenoceptors	A	pKi	7.31	7.31	7.31	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKd	7.64	7.64	7.64	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	5.30	5.82	6.40	ChEMBL
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	6.14	7.41	7.83	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.99	7.12	7.26	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKd	7.80	7.80	7.80	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	7.33	7.33	7.33	PDSP Ki database
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	7.20	7.20	7.20	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
β₁	ADRB1	Mouse	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	8.11	8.11	8.11	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	7.00	7.45	7.90	Guide to Pharmacology
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.30	6.60	6.90	Guide to Pharmacology
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	6.79	6.79	6.79	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.75	6.21	6.66	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKd	4.81	5.85	6.89	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.53	5.53	5.53	PDSP Ki database
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.77	5.77	5.77	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	8.17	8.17	8.17	Drug Central

Showing 1 to 20 of 25 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	B0FL73	Guinea pig	Adrenoceptors	A	pIC50	6.50	6.61	6.72	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	6.75	6.75	6.75	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.59	5.59	5.59	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	7.30	7.30	7.30	ChEMBL
Y₁	NPY1R	Human	Neuropeptide Y	A	pEC50	4.46	4.74	5.02	ChEMBL
Y₂	NPY2R	Human	Neuropeptide Y	A	pEC50	4.79	4.79	4.79	ChEMBL

Showing 1 to 6 of 6 entries

metoprolol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 6

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C07A, C07C, C07B, C07F	0.601	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Angina pectoris, unspecified	BA40.Z	C07A, C07C, C07B, C07F	0.605	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C07A, C07C, C07B, C07F	0.605	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Beta thalassaemia	3A50.2	C07A, C07C, C07B, C07F	0.074	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiac arrest, unspecified	MC82.Z	C07A, C07C, C07B, C07F	0.533	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic obstructive pulmonary disease, unspecified	CA22.Z	C07A, C07C, C07B, C07F	0.566	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Congestive heart failure	BD10	C07A, C07C, C07B, C07F	0.600	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Duchenne muscular dystrophy	8C70.1	C07A, C07C, C07B, C07F	0.515	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C07A, C07C, C07B, C07F	0.665	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C07A, C07C, C07B, C07F	0.607	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hypertrophic cardiomyopathy, unspecified	BC43.1Z	C07A, C07C, C07B, C07F	0.538	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Prader-Willi syndrome	LD90.3	C07A, C07C, C07B, C07F	0.074	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	C07A, C07C, C07B, C07F	0.588	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Type 2 diabetes mellitus	5A11	C07A, C07C, C07B, C07F	0.401	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular fibrillation	BC71.1	C07A, C07C, C07B, C07F	0.375	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ventricular tachycardia, unspecified	BC71.0Z	C07A, C07C, C07B, C07F	0.541	2	Yes

Showing 1 to 16 of 16 entries

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metoprolol

metoprolol

Chemical Properties

Database connections

Bioactivities

metoprolol

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information