Biased Signaling Atlas

morphine

Agent/drug
Bioactivity

morphine

SMILES	CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
InChIKey	BQJCRHHNABKAKU-KBQPJGBKSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	0
Molecular weight (Da)	285.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8EF6

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
δ	O57585	Zebrafish	Opioid	A	pKi	6.65	6.65	6.65	ChEMBL
δ	OPRD	Mouse	Opioid	A	pKi	7.00	7.00	7.00	ChEMBL
δ	OPRD	Rat	Opioid	A	pKi	6.17	7.22	8.74	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	6.15	6.61	7.29	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	8.18	8.18	8.18	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	8.15	8.15	8.15	Drug Central
δ	O57585	Zebrafish	Opioid	A	pKi	8.18	8.18	8.18	Drug Central
δ	OPRD	Rat	Opioid	A	pKi	8.06	8.06	8.06	Drug Central
κ	OPRK	Human	Opioid	A	pKi	7.30	7.30	7.30	Guide to Pharmacology
κ	OPRK	Rat	Opioid	A	pKi	6.70	6.85	7.00	Guide to Pharmacology
κ	OPRK	Rat	Opioid	A	pKi	6.95	7.16	7.57	ChEMBL
κ	OPRK	Mouse	Opioid	A	pKi	5.81	6.16	6.52	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pKi	5.19	6.90	7.62	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.72	7.12	8.16	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.16	8.16	8.16	Drug Central
κ	OPRK	Mouse	Opioid	A	pKi	8.19	8.19	8.19	Drug Central
κ	OPRK	Rat	Opioid	A	pKi	8.12	8.12	8.12	Drug Central
κ	OPRK	Guinea pig	Opioid	A	pKi	8.12	8.12	8.12	Drug Central
μ	OPRM	Human	Opioid	A	pKi	9.00	9.00	9.00	Guide to Pharmacology

Showing 1 to 20 of 30 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Mouse	Opioid	A	pIC50	5.80	6.27	6.81	ChEMBL
δ	OPRD	Rat	Opioid	A	pIC50	6.17	6.71	8.13	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	6.37	6.64	6.82	ChEMBL
δ	OPRD	Human	Opioid	A	pEC50	6.11	6.72	7.81	ChEMBL
κ	OPRK	Mouse	Opioid	A	pEC50	6.40	6.40	6.40	ChEMBL
κ	OPRK	Mouse	Opioid	A	pIC50	6.84	6.84	6.84	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pIC50	5.62	6.63	8.74	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.77	6.21	6.66	ChEMBL
κ	OPRK	Human	Opioid	A	pEC50	6.32	6.36	6.48	ChEMBL
μ	OPRM	Mouse	Opioid	A	pIC50	5.85	7.39	8.90	ChEMBL
μ	OPRM	Mouse	Opioid	A	pEC50	6.31	6.97	7.92	ChEMBL
μ	OPRM	Rat	Opioid	A	pIC50	5.01	8.25	9.85	ChEMBL
μ	OPRM	Rat	Opioid	A	pEC50	6.71	6.97	7.67	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	6.30	7.37	8.43	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	6.39	8.07	9.24	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	8.10	8.10	8.10	Drug Central

Showing 1 to 16 of 16 entries

morphine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 6

Phase III 24

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8EF6

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Chronic pain, unspecified	MG30.Z	A07D, N02A	0.586	4	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Disorders due to use of opioids, unspecified	6C43.Z	A07D, N02A	0.580	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Dyspnoea	MD11.5	A07D, N02A	0.371	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Idiopathic pulmonary fibrosis	CB03.4	A07D, N02A	0.095	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Neonatal withdrawal syndrome from maternal use of drugs of addiction	KD35	A07D, N02A	0.007	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Obstructive sleep apnoea	7A41	A07D, N02A	0.370	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Opioid dependence, unspecified	6C43.2Z	A07D, N02A	0.493	3	Yes
OPRD	δ receptor	Opioid receptors	Peptide receptors	Class A	Pain, unspecified	MG3Z	A07D, N02A	0.608	4	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	A07D, N02A	0.009	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Cardiac arrest, unspecified	MC82.Z	A07D, N02A	0.001	1	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Chronic pain, unspecified	MG30.Z	A07D, N02A	0.591	4	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Disorders due to use of opioids, unspecified	6C43.Z	A07D, N02A	0.601	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Dyspnoea	MD11.5	A07D, N02A	0.374	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Idiopathic pulmonary fibrosis	CB03.4	A07D, N02A	0.092	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Neonatal withdrawal syndrome from maternal use of drugs of addiction	KD35	A07D, N02A	0.292	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Obstructive sleep apnoea	7A41	A07D, N02A	0.370	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Opioid dependence, unspecified	6C43.2Z	A07D, N02A	0.518	3	Yes
OPRK	κ receptor	Opioid receptors	Peptide receptors	Class A	Pain, unspecified	MG3Z	A07D, N02A	0.608	4	Yes
OPRM	μ receptor	Opioid receptors	Peptide receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	A07D, N02A	0.385	3	Yes
OPRM	μ receptor	Opioid receptors	Peptide receptors	Class A	Cardiac arrest, unspecified	MC82.Z	A07D, N02A	0.038	1	Yes

Showing 1 to 20 of 31 entries

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morphine

morphine

Chemical Properties

Database connections

Bioactivities

morphine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information