mozavaptan


SMILES O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C
InChIKey WRNXUQJJCIZICJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 427.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Human Vasopressin and oxytocin A pKi 6.82 6.82 6.82 PDSP Ki database
V1A V1AR Human Vasopressin and oxytocin A pKi 8.17 8.17 8.17 Drug Central
V1A V1AR Human Vasopressin and oxytocin A pKi 6.71 6.71 6.71 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pKi 6.8 6.95 7.1 Guide to Pharmacology
V1B V1BR Human Vasopressin and oxytocin A pKi 8.32 8.32 8.32 Drug Central
V1B V1BR Human Vasopressin and oxytocin A pKi 5.0 5.0 5.0 PDSP Ki database
V1B V1BR Human Vasopressin and oxytocin A pKi 4.8 4.8 4.8 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 8.1 8.1 8.1 Drug Central
V2 V2R Human Vasopressin and oxytocin A pKi 8.03 8.03 8.03 PDSP Ki database
V2 V2R Human Vasopressin and oxytocin A pKi 8.01 8.02 8.03 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pKi 7.4 7.75 8.1 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKi 8.21 8.21 8.21 Drug Central
OT OXYR Human Vasopressin and oxytocin A pKi 6.18 6.18 6.18 ChEMBL
V1B V1BR Rat Vasopressin and oxytocin A pKi 5.0 5.0 5.0 PDSP Ki database
V1A V1AR Rat Vasopressin and oxytocin A pKi 6.28 6.54 6.71 PDSP Ki database
V1A V1AR Rat Vasopressin and oxytocin A pKi 6.3 6.3 6.3 Guide to Pharmacology
V2 V2R Rat Vasopressin and oxytocin A pKi 7.37 7.93 8.21 PDSP Ki database
V2 V2R Rat Vasopressin and oxytocin A pKi 7.4 7.8 8.2 Guide to Pharmacology
OT OXYR Rat Vasopressin and oxytocin A pKi 5.81 5.81 5.81 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V2 V2R Rat Vasopressin and oxytocin A pIC50 6.52 7.22 7.92 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pIC50 6.3 6.3 6.3 ChEMBL
V1A V1AR Rat Vasopressin and oxytocin A pIC50 8.23 8.23 8.23 Drug Central
V1A V1AR Rat Vasopressin and oxytocin A pIC50 5.85 5.85 5.85 ChEMBL
V2 V2R Rat Vasopressin and oxytocin A pIC50 8.1 8.1 8.1 Drug Central