MT-II


SMILES None
InChIKey JDKLPDJLXHXHNV-MFVUMRCOSA-N
Sequence XDHFRWK

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pKi 9.88 9.9 9.95 ChEMBL
MC3 MC3R Human Melanocortin A pKi 7.73 8.01 8.4 ChEMBL
MC4 MC4R Human Melanocortin A pKi 8.9 9.08 9.34 ChEMBL
MC3 MC3R Human Melanocortin A pKi 8.3 8.3 8.3 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 8.2 8.5 8.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC5 MC5R Mouse Melanocortin A pEC50 9.24 9.75 10.17 ChEMBL
MC1 MSHR Mouse Melanocortin A pEC50 9.66 10.49 10.7 ChEMBL
MC3 MC3R Mouse Melanocortin A pEC50 9.46 9.74 9.89 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 10.06 10.22 10.4 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 6.96 9.19 10.0 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 8.17 9.22 10.0 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 7.47 8.31 8.83 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 7.36 8.07 8.82 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 8.01 8.63 8.92 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 7.47 8.72 10.21 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 8.13 8.8 9.14 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.0 8.85 10.4 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 9.4 9.4 9.4 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pIC50 9.0 9.0 9.0 Guide to Pharmacology