nortriptyline


SMILES CNCCC=C1c2ccccc2CCc2c1cccc2
InChIKey PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 263.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 8.2 8.2 8.2 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.84 5.84 5.84 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 6.94 6.94 6.94 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 6.91 6.91 6.91 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.87 6.87 6.87 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.37 7.37 7.37 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.52 7.52 7.52 ChEMBL
H2 HRH2 Human Histamine A pKi 5.64 5.64 5.64 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.89 7.89 7.89 ChEMBL
H1 HRH1 Human Histamine A pKi 8.23 8.23 8.23 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.44 7.44 7.44 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.97 5.97 5.97 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.56 6.56 6.56 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.57 6.57 6.57 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.59 6.63 6.67 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.07 7.07 7.07 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.91 6.91 6.91 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.21 7.21 7.21 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.82 7.82 7.82 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.82 8.03 8.2 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.59 5.59 5.59 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 7.34 7.34 7.34 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.4 7.4 7.4 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.3 7.3 7.3 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.08 7.08 7.08 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.01 7.01 7.01 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 7.52 7.52 7.52 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.16 8.16 8.16 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
D1 DRD1 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
D2 DRD2 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
D3 DRD3 Human Dopamine A pKi 8.14 8.14 8.14 Drug Central
H1 HRH1 Human Histamine A pKd 8.1 8.1 8.1 Drug Central
H2 HRH2 Human Histamine A pKi 8.25 8.25 8.25 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.53 6.53 6.53 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pIC50 10.3 10.3 10.3 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.5 5.5 5.5 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 6.68 6.68 6.68 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 6.52 8.46 10.4 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.75 6.28 6.8 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 6.56 6.56 6.56 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 7.03 7.03 7.03 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 7.57 7.57 7.57 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.69 6.69 6.69 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.63 5.63 5.63 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 7.02 7.02 7.02 ChEMBL
H1 HRH1 Human Histamine A pIC50 7.3 7.3 7.3 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.77 6.77 6.77 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.73 5.73 5.73 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.13 6.13 6.13 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.27 6.27 6.27 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 6.26 6.26 6.26 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.87 6.87 6.87 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.46 6.46 6.46 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.8 7.8 7.8 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 7.09 7.09 7.09 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.75 6.75 6.75 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.29 7.29 7.29 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.24 8.24 8.24 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 7.1 7.1 7.1 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.98 7.98 7.98 Drug Central
H1 HRH1 Rat Histamine A pIC50 7.99 7.99 7.99 Drug Central