octreotide
| SMILES | None |
| InChIKey | DEQANNDTNATYII-UHFFFAOYSA-N |
| Sequence | FCFWKTCT |
Chemical properties
| Hydrogen bond acceptors | None |
| Hydrogen bond donors | None |
| Rotatable bonds | None |
| Molecular weight (Da) |
Drug properties
| Molecular type | Peptide |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| SST2 | SSR2 | Human | Somatostatin | A | pKi | 8.7 | 9.3 | 9.9 | Guide to Pharmacology |
| SST3 | SSR3 | Human | Somatostatin | A | pKi | 7.4 | 8.0 | 8.6 | Guide to Pharmacology |
| SST5 | SSR5 | Human | Somatostatin | A | pKi | 7.2 | 8.35 | 9.5 | Guide to Pharmacology |
| SST5 | SSR5 | Rat | Somatostatin | A | pKi | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
| SST2 | SSR2 | Rat | Somatostatin | A | pKi | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
| SST5 | SSR5 | Mouse | Somatostatin | A | pKi | 7.7 | 8.8 | 9.9 | Guide to Pharmacology |
| SST3 | SSR3 | Rat | Somatostatin | A | pKi | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
| SST2 | SSR2 | Mouse | Somatostatin | A | pKi | 7.5 | 8.35 | 9.2 | Guide to Pharmacology |
| SST4 | SSR4 | Human | Somatostatin | A | pKi | 7.18 | 7.18 | 7.18 | ChEMBL |
| SST1 | SSR1 | Human | Somatostatin | A | pKi | 5.92 | 6.29 | 6.65 | PDSP Ki database |
| SST2 | SSR2 | Human | Somatostatin | A | pKi | 8.57 | 9.24 | 9.92 | PDSP Ki database |
| SST3 | SSR3 | Human | Somatostatin | A | pKi | 6.82 | 7.99 | 8.6 | PDSP Ki database |
| SST4 | SSR4 | Human | Somatostatin | A | pKi | 5.15 | 6.34 | 9.7 | PDSP Ki database |
| SST5 | SSR5 | Human | Somatostatin | A | pKi | 6.0 | 8.09 | 9.48 | PDSP Ki database |
| SST5 | SSR5 | Rat | Somatostatin | A | pKi | 7.77 | 8.5 | 9.24 | PDSP Ki database |
| SST3 | SSR3 | Mouse | Somatostatin | A | pKi | 6.82 | 7.95 | 8.52 | PDSP Ki database |
| SST4 | SSR4 | Mouse | Somatostatin | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| SST2 | SSR2 | Mouse | Somatostatin | A | pKi | 7.46 | 8.65 | 9.3 | PDSP Ki database |
| SST4 | SSR4 | Rat | Somatostatin | A | pKi | 9.24 | 9.49 | 9.74 | PDSP Ki database |
| μ | OPRM | Human | Opioid | A | pKi | 7.92 | 7.92 | 7.92 | PDSP Ki database |
| SST2 | SSR2 | Rat | Somatostatin | A | pKi | 8.7 | 8.7 | 8.7 | PDSP Ki database |
| SST3 | SSR3 | Rat | Somatostatin | A | pKi | 7.85 | 7.85 | 7.85 | PDSP Ki database |
| μ | OPRM | Human | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| SST3 | SSR3 | Human | Somatostatin | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| SST4 | SSR4 | Human | Somatostatin | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| SST2 | SSR2 | Rat | Somatostatin | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| SST5 | SSR5 | Mouse | Somatostatin | A | pKi | 8.0 | 8.0 | 8.0 | Drug Central |
| SST3 | SSR3 | Rat | Somatostatin | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| SST1 | SSR1 | Human | Somatostatin | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| SST2 | SSR2 | Human | Somatostatin | A | pKi | 9.4 | 9.4 | 9.4 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| SST3 | SSR3 | Mouse | Somatostatin | A | pIC50 | 8.5 | 8.5 | 8.5 | Guide to Pharmacology |
| SST2 | SSR2 | Human | Somatostatin | A | pEC50 | 7.97 | 7.97 | 7.97 | Drug Central |
| SST5 | SSR5 | Human | Somatostatin | A | pIC50 | 8.07 | 8.07 | 8.07 | Drug Central |
| SST5 | SSR5 | Rat | Somatostatin | A | pIC50 | 8.05 | 8.05 | 8.05 | Drug Central |
| SST3 | SSR3 | Mouse | Somatostatin | A | pIC50 | 8.07 | 8.07 | 8.07 | Drug Central |
| SST2 | SSR2 | Mouse | Somatostatin | A | pIC50 | 8.02 | 8.02 | 8.02 | Drug Central |
| SST2 | SSR2 | Human | Somatostatin | A | pEC50 | 10.52 | 10.52 | 10.52 | ChEMBL |
| SST5 | SSR5 | Human | Somatostatin | A | pIC50 | 7.66 | 7.66 | 7.66 | ChEMBL |