Biased Signaling Atlas

oxymetazoline

SMILES	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C
InChIKey	WYWIFABBXFUGLM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	260.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Structure pdb	7EJK 7YM8
Ligand site mutations	α_1A α_1B α_2A α_2B

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.49	8.49	8.49	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	9.5	9.5	9.5	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	9.04	9.04	9.04	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	9.59	9.59	9.59	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.6	8.93	9.09	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.02	8.02	8.02	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.04	8.04	8.04	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	9.52	9.52	9.52	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	9.4	9.4	9.4	Guide to Pharmacology
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	8.89	8.89	8.89	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	9.4	9.4	9.4	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	8.2	8.2	8.2	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.43	6.43	6.43	ChEMBL
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	6.65	6.65	6.65	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.59	6.59	6.59	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.71	5.71	5.71	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.83	6.83	6.83	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.3	6.55	6.8	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.52	6.52	6.52	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.19	6.19	6.19	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.92	6.92	6.92	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.11	6.11	6.11	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	6.34	6.34	6.34	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	8.2	8.2	8.2	Drug Central
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	6.02	6.02	6.02	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	8.22	8.22	8.22	Drug Central
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.2	7.7	8.2	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	7.88	7.88	7.88	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.8	7.99	8.19	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.8	7.8	7.8	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	7.5	7.6	7.7	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.1	8.1	8.1	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.2	5.85	6.5	Guide to Pharmacology
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	6.69	6.69	6.69	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.16	6.16	6.16	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.42	6.42	6.42	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.08	6.08	6.08	PDSP Ki database
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	6.8	6.8	6.8	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.08	6.08	6.08	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.3	5.85	6.4	Guide to Pharmacology
α_1D	G3V8W0	Rat	Adrenoceptors	A	pKi	6.2	6.2	6.2	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.85	5.86	5.87	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.3	7.95	8.6	Guide to Pharmacology
α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	7.68	7.68	7.68	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	8.82	8.82	8.82	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.79	8.51	9.54	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.01	8.58	9.1	PDSP Ki database
α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	7.45	7.97	8.5	PDSP Ki database
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	7.59	7.7	7.81	PDSP Ki database
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.02	8.02	8.02	Drug Central
α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.0	5.6	6.2	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.27	5.75	6.24	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.53	6.02	6.67	PDSP Ki database
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	6.51	6.83	7.15	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.4	6.55	6.7	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.42	7.74	9.0	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.62	7.18	7.51	PDSP Ki database
α_2C	ADA2C	North American opossum	Adrenoceptors	A	pKi	7.14	7.14	7.14	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central

Showing 1 to 75 of 75 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.25	8.25	8.25	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	7.16	7.16	7.16	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.08	8.08	8.08	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	8.7	8.7	8.7	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pEC50	6.86	6.86	6.86	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.89	5.89	5.89	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.51	5.51	5.51	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.24	6.24	6.24	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.78	5.78	5.78	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.9	5.08	5.25	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	5.49	5.49	5.49	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	5.88	5.88	5.88	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.4	5.4	5.4	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.4	4.45	4.5	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	7.2	8.25	9.3	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pEC50	6.54	6.54	6.54	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.42	7.42	7.42	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	6.46	7.39	7.7	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	6.7	7.05	7.4	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pEC50	6.47	6.47	6.47	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.91	5.91	5.91	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	5.6	6.45	7.3	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.55	5.55	5.55	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.4	8.4	8.4	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	8.48	8.48	8.48	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.64	7.64	7.64	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	7.7	7.7	7.7	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.8	8.8	8.8	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.89	5.89	5.89	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	6.92	6.92	6.92	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.4	7.8	8.2	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.58	5.58	5.58	ChEMBL

Showing 1 to 32 of 32 entries

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oxymetazoline

Chemical properties

Drug properties

Database connections

Bioactivities