Biased Signaling Atlas

oxytocin

Agent/drug
Bioactivity

oxytocin

SMILES	None
InChIKey	XNOPRXBHLZRZKH-DSZYJQQASA-N
Sequence	CYIQNCPLG

Chemical Properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7QVM 7RYC

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	8.20	8.90	9.60	Guide to Pharmacology
OT	OXYR	Human	Vasopressin and oxytocin	A	pKd	8.20	8.85	9.50	Guide to Pharmacology
OT	OXYR	Rat	Vasopressin and oxytocin	A	pKi	8.70	8.70	8.70	Guide to Pharmacology
OT	OXYR	Rat	Vasopressin and oxytocin	A	pKi	8.77	8.91	9.05	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pKd	8.17	8.17	8.17	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	8.02	8.85	9.36	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	9.15	9.23	9.30	PDSP Ki database
OT	OXYR	Rat	Vasopressin and oxytocin	A	pKi	8.72	8.89	9.05	PDSP Ki database
OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	8.04	8.04	8.04	Drug Central
OT	OXYR	Rat	Vasopressin and oxytocin	A	pKi	8.04	8.04	8.04	Drug Central
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	6.90	7.60	8.30	Guide to Pharmacology
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKd	6.90	6.90	6.90	Guide to Pharmacology
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	6.10	6.10	6.10	Guide to Pharmacology
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	6.92	7.25	7.70	ChEMBL
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	7.23	7.29	7.34	PDSP Ki database
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	8.21	8.21	8.21	Drug Central
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	6.91	6.91	6.91	PDSP Ki database
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKi	5.70	6.35	7.00	Guide to Pharmacology
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKd	5.80	5.80	5.80	Guide to Pharmacology
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKi	5.75	5.75	5.75	ChEMBL

Showing 1 to 20 of 29 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

OT	OXYR	Mouse	Vasopressin and oxytocin	A	pEC50	8.70	8.70	8.70	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pIC50	8.57	8.57	8.57	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pEC50	7.58	8.83	11.00	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pEC50	6.58	8.28	9.74	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pEC50	8.16	8.16	8.16	Drug Central
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pEC50	6.62	7.73	9.70	ChEMBL
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pEC50	8.20	8.20	8.20	Drug Central
V₂	V2R	Human	Vasopressin and oxytocin	A	pEC50	6.09	7.11	8.14	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pEC50	8.21	8.21	8.21	Drug Central

Showing 1 to 9 of 9 entries

oxytocin

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Endogenous
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 12

Phase II 22

Phase III 6

Phase IV 3

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7QVM 7RYC

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Acute myocardial infarction, unspecified	2	BA41.Z	G02A, H01B	0.041
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Alcohol dependence, unspecified	3	6C40.2Z	G02A, H01B	0.491
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Alcohol withdrawal, unspecified	2	6C40.4Z	G02A, H01B	0.083
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Allergic or hypersensitivity conditions of unspecified type	1	4A8Z	G02A, H01B	0.037
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Anorexia Nervosa, unspecified	1	6B80.Z	G02A, H01B	0.026
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Attention deficit hyperactivity disorder, presentation unspecified	1	6A05.Z	G02A, H01B	0.054
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Autism spectrum disorder, unspecified	3	6A02.Z	G02A, H01B	0.310
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	COVID-19	2	RA01	G02A, H01B	0.075
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Cardiac arrhythmia, unspecified	1	BC9Z	G02A, H01B	0.018
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Chronic pain, unspecified	2	MG30.Z	G02A, H01B	0.478
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	G02A, H01B	0.098
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Depressive disorders, unspecified	2	6A7Z	G02A, H01B	0.089
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Disorders due to substance use, unspecified	1	6C4Z	G02A, H01B	0.020
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Disorders due to use of opioids, unspecified	1	6C43.Z	G02A, H01B	0.046
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Fragile X chromosome	2	LD55	G02A, H01B	0.074
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Frontotemporal dementia	2	6D83	G02A, H01B	0.097
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Gastroparesis	1	DA41.00	G02A, H01B	0.019
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Haemorrhage, not elsewhere classified	4	MG27	G02A, H01B	0.572
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Hypertonic, incoordinate, or prolonged uterine contractions	3	JB02.4	G02A, H01B	0.437
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Mental, behavioural or neurodevelopmental disorders, unspecified	2	6E8Z	G02A, H01B	0.094

Showing 1 to 20 of 40 entries

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oxytocin

oxytocin

Chemical Properties

Database connections

Bioactivities

oxytocin

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information