PGF2α
| SMILES | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O |
| InChIKey | PXGPLTODNUVGFL-YNNPMVKQSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 4 |
| Rotatable bonds | 12 |
| Molecular weight (Da) | 354.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Endogenous |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| DP1 | PD2R | Human | Prostanoid | A | pKi | 6.1 | 6.25 | 6.4 | Guide to Pharmacology |
| DP2 | PD2R2 | Human | Prostanoid | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| EP1 | PE2R1 | Human | Prostanoid | A | pKi | 6.2 | 6.25 | 6.3 | Guide to Pharmacology |
| EP2 | PE2R2 | Human | Prostanoid | A | pKi | 5.2 | 5.6 | 6.0 | Guide to Pharmacology |
| EP3 | PE2R3 | Human | Prostanoid | A | pKi | 7.42 | 7.42 | 7.42 | Guide to Pharmacology |
| EP4 | PE2R4 | Human | Prostanoid | A | pKi | 9.1 | 9.29 | 9.49 | Guide to Pharmacology |
| FP | PF2R | Human | Prostanoid | A | pKi | 7.9 | 8.2 | 8.5 | Guide to Pharmacology |
| TP | TA2R | Human | Prostanoid | A | pKi | 5.1 | 5.1 | 5.1 | Guide to Pharmacology |
| EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 5.9 | 5.9 | 5.9 | Guide to Pharmacology |
| EP3 | PE2R3 | Rat | Prostanoid | A | pKi | 6.67 | 6.67 | 6.67 | Guide to Pharmacology |
| EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 7.12 | 7.12 | 7.12 | Guide to Pharmacology |
| EP1 | PE2R1 | Rat | Prostanoid | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| FP | PF2R | Mouse | Prostanoid | A | pKi | 8.5 | 8.5 | 8.5 | Guide to Pharmacology |
| DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| EP2 | PE2R2 | Rat | Prostanoid | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
| EP4 | PE2R4 | Rat | Prostanoid | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| FP | PF2R | Bovine | Prostanoid | A | pKi | 6.89 | 6.89 | 6.89 | ChEMBL |
| FP | PF2R | Human | Prostanoid | A | pKi | 6.92 | 6.92 | 6.92 | ChEMBL |
| EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 5.89 | 5.89 | 5.89 | PDSP Ki database |
| EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 7.12 | 7.12 | 7.12 | PDSP Ki database |
| FP | PF2R | Mouse | Prostanoid | A | pKi | 8.47 | 8.47 | 8.47 | PDSP Ki database |
| FP | PF2R | Bovine | Prostanoid | A | pKi | 6.92 | 6.92 | 6.92 | PDSP Ki database |
| EP3 | PE2R3 | Bovine | Prostanoid | A | pKi | 7.43 | 7.53 | 7.62 | PDSP Ki database |
| FP | PF2R | Human | Prostanoid | A | pKi | 7.32 | 7.91 | 8.49 | PDSP Ki database |
| EP1 | PE2R1 | Human | Prostanoid | A | pKi | 6.26 | 6.26 | 6.26 | PDSP Ki database |
| EP4 | PE2R4 | Human | Prostanoid | A | pKi | 6.02 | 6.28 | 6.54 | PDSP Ki database |
| DP1 | PD2R | Human | Prostanoid | A | pKi | 6.06 | 6.06 | 6.06 | PDSP Ki database |
| EP3 | PE2R3 | Human | Prostanoid | A | pKi | 7.42 | 7.42 | 7.42 | PDSP Ki database |
| IP | PI2R | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| TP | TA2R | Mouse | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| IP | PI2R | Mouse | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| DP1 | PD2R | Rat | Prostanoid | A | pKi | 6.16 | 6.16 | 6.16 | PDSP Ki database |
| DP2 | PD2R2 | Human | Prostanoid | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| EP2 | PE2R2 | Human | Prostanoid | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| FP | PF2R | Human | Prostanoid | A | pKd | 8.08 | 8.08 | 8.08 | Drug Central |
| TP | TA2R | Human | Prostanoid | A | pKi | 8.29 | 8.29 | 8.29 | Drug Central |
| EP1 | PE2R1 | Mouse | Prostanoid | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| EP3 | PE2R3 | Mouse | Prostanoid | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| EP1 | PE2R1 | Rat | Prostanoid | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| FP | PF2R | Bovine | Prostanoid | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| EP2 | PE2R2 | Rat | Prostanoid | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| EP4 | PE2R4 | Rat | Prostanoid | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| EP4 | PE2R4 | Human | Prostanoid | A | pEC50 | 6.05 | 6.05 | 6.05 | Guide to Pharmacology |
| EP3 | PE2R3 | Rat | Prostanoid | A | pEC50 | 8.38 | 8.38 | 8.38 | Guide to Pharmacology |
| FP | PF2R | Bovine | Prostanoid | A | pIC50 | 6.85 | 6.85 | 6.85 | ChEMBL |
| FP | PF2R | Mouse | Prostanoid | A | pEC50 | 7.61 | 7.76 | 7.9 | ChEMBL |
| FP | PF2R | Human | Prostanoid | A | pIC50 | 7.37 | 8.16 | 8.6 | ChEMBL |
| FP | PF2R | Human | Prostanoid | A | pEC50 | 7.1 | 7.36 | 7.61 | ChEMBL |
| EP1 | PE2R1 | Human | Prostanoid | A | pIC50 | 6.42 | 6.54 | 6.66 | ChEMBL |
| EP1 | PE2R1 | Human | Prostanoid | A | pEC50 | 6.22 | 6.22 | 6.22 | ChEMBL |
| EP3 | PE2R3 | Human | Prostanoid | A | pIC50 | 6.49 | 6.72 | 6.96 | ChEMBL |
| EP3 | PE2R3 | Human | Prostanoid | A | pEC50 | 5.64 | 5.64 | 5.64 | ChEMBL |
| TP | TA2R | Human | Prostanoid | A | pEC50 | 5.85 | 5.85 | 5.85 | ChEMBL |
| DP1 | PD2R | Human | Prostanoid | A | pIC50 | 8.27 | 8.27 | 8.27 | Drug Central |
| EP1 | PE2R1 | Human | Prostanoid | A | pIC50 | 8.18 | 8.18 | 8.18 | Drug Central |
| EP3 | PE2R3 | Human | Prostanoid | A | pIC50 | 8.16 | 8.16 | 8.16 | Drug Central |
| EP4 | PE2R4 | Human | Prostanoid | A | pIC50 | 8.27 | 8.27 | 8.27 | Drug Central |
| EP3 | PE2R3 | Rat | Prostanoid | A | pEC50 | 8.08 | 8.08 | 8.08 | Drug Central |
| FP | PF2R | Mouse | Prostanoid | A | pEC50 | 8.1 | 8.1 | 8.1 | Drug Central |
| DP1 | PD2R | Human | Prostanoid | A | pIC50 | 5.35 | 5.35 | 5.35 | ChEMBL |
| EP4 | PE2R4 | Human | Prostanoid | A | pIC50 | 5.38 | 5.38 | 5.38 | ChEMBL |