pramipexole


SMILES CCCN[C@H]1CCc2c(C1)sc(n2)N
InChIKey FASDKYOPVNHBLU-ZETCQYMHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 211.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7CMU
Ligand site mutations D3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Bovine Dopamine A pKd 8.8 8.8 8.8 ChEMBL
D3 DRD3 Rat Dopamine A pKi 9.11 9.19 9.35 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.17 7.17 7.17 ChEMBL
H4 HRH4 Human Histamine A pKd 7.8 7.8 7.8 ChEMBL
H2 HRH2 Human Histamine A pKi 4.86 5.21 5.57 ChEMBL
H2 HRH2 Human Histamine A pKd 7.91 7.91 7.91 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.92 5.92 5.92 ChEMBL
H1 HRH1 Human Histamine A pKd 8.35 8.35 8.35 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.86 7.9 9.31 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.41 7.96 8.51 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 4.0 4.0 4.0 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.42 8.52 9.18 ChEMBL
D3 DRD3 Human Dopamine A pKd 10.59 10.59 10.59 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.2 6.92 8.33 ChEMBL
D2 DRD2 Human Dopamine A pKd 10.83 10.83 10.83 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 5.39 5.78 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.19 5.68 6.16 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.19 5.19 5.19 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.46 5.46 5.46 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.08 5.27 5.45 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.93 5.93 5.93 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.12 7.12 7.12 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.77 6.45 7.12 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 6.2 6.69 7.17 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 7.28 7.28 7.28 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.0 6.14 7.28 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 8.4 8.4 8.4 Drug Central
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.77 6.51 8.51 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.1 6.25 7.4 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.4 8.55 8.7 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.98 8.67 9.64 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 6.89 7.21 7.54 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
H2 HRH2 Human Histamine A pKi 5.57 5.57 5.57 PDSP Ki database
H2 HRH2 Human Histamine A pKi 8.25 8.25 8.25 Drug Central
H4 HRH4 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
δ OPRD Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
μ OPRM Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 9.05 9.05 9.05 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 8.03 8.03 8.03 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
κ OPRK Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKd 8.06 8.06 8.06 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.07 8.07 8.07 Drug Central
H3 HRH3 Guinea pig Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pEC50 9.68 9.68 9.68 ChEMBL
D3 DRD3 Rat Dopamine A pIC50 8.11 8.11 8.11 ChEMBL
H2 HRH2 Human Histamine A pEC50 6.78 6.78 6.78 ChEMBL
D4 DRD4 Human Dopamine A pEC50 7.82 7.82 7.82 ChEMBL
D2 DRD2 Rat Dopamine A pEC50 7.67 8.06 8.77 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.33 5.84 6.35 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 5.93 5.93 5.93 ChEMBL
D3 DRD3 Human Dopamine A pEC50 8.27 8.8 9.09 ChEMBL
D2 DRD2 Human Dopamine A pEC50 7.0 7.83 8.3 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.23 8.23 8.23 Drug Central
D2 DRD2 Human Dopamine A pEC50 8.18 8.18 8.18 Drug Central
D3 DRD3 Human Dopamine A pEC50 8.06 8.06 8.06 Drug Central