piribedil


SMILES c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2
InChIKey OQDPVLVUJFGPGQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 298.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 6.1 6.1 6.1 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 7.2 7.2 7.2 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 6.8 6.85 6.9 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 6.5 6.5 6.5 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 5.21 5.21 5.21 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 6.09 6.38 6.66 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.05 7.05 7.05 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.54 6.54 6.54 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.16 7.16 7.16 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.88 6.88 6.88 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.63 6.63 6.63 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 6.52 6.52 6.52 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.35 6.35 6.35 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.92 5.92 5.92 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
D2 DRD2 Human Dopamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.1 7.1 7.1 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 8.19 8.19 8.19 Drug Central
D2 DRD2 Rat Dopamine A pKi 6.74 6.74 6.74 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.85 4.95 5.05 ChEMBL