pitolisant


SMILES Clc1ccc(cc1)CCCOCCCN1CCCCC1
InChIKey NNACHAUCXXVJSP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 295.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 5.78 5.78 5.78 Guide to Pharmacology
H2 HRH2 Human Histamine A pKi 4.96 4.96 4.96 Guide to Pharmacology
H4 HRH4 Human Histamine A pKi 4.0 4.0 4.0 Guide to Pharmacology
H3 HRH3 Guinea pig Histamine A pKd 8.25 8.25 8.25 ChEMBL
H3 HRH3 Guinea pig Histamine A pKi 9.8 9.8 9.8 ChEMBL
H3 HRH3 Rat Histamine A pKi 7.77 7.77 7.77 ChEMBL
H1 HRH1 Human Histamine A pKi 5.94 5.94 5.94 ChEMBL
H3 HRH3 Human Histamine A pKi 4.87 8.39 9.8 ChEMBL
H3 HRH3 Guinea pig Histamine A pKi 8.01 8.01 8.01 Drug Central
H1 HRH1 Human Histamine A pKi 8.23 8.23 8.23 Drug Central
H2 HRH2 Human Histamine A pKi 8.3 8.3 8.3 Drug Central
H3 HRH3 Human Histamine A pKi 8.01 8.01 8.01 Drug Central
H3 HRH3 Rat Histamine A pKi 8.11 8.11 8.11 Drug Central
H3 HRH3 Mouse Histamine A pKi 8.11 8.11 8.11 Drug Central
H3 HRH3 Human Histamine A pKi 8.06 8.32 8.57 Guide to Pharmacology
H3 HRH3 Mouse Histamine A pKi 7.85 7.85 7.85 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Guinea pig Histamine A pEC50 8.82 8.82 8.82 ChEMBL
H3 HRH3 Human Histamine A pIC50 7.72 7.82 7.92 ChEMBL
H3 HRH3 Human Histamine A pEC50 8.1 8.1 8.1 ChEMBL