prazosin
| SMILES | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 |
| InChIKey | IENZQIKPVFGBNW-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 8 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 383.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
GTP
| Uniprot
| Species
| Family
| Class
| Type
| Min | Avg | Max | Database
|
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.63 | 5.63 | 5.63 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.61 | 6.31 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.1 | 5.82 | 6.54 | PDSP Ki database |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 9.48 | 9.48 | 9.48 | ChEMBL |
| 5-HT1D | F1MMU1 | Bovine | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.02 | 8.02 | 8.02 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 5.15 | 6.92 | 10.15 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.72 | 6.48 | PDSP Ki database |
| 5-HT2A | 5HT2A | Pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 5.58 | 5.58 | 5.58 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| 5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.0 | 5.01 | 5.06 | PDSP Ki database |
| D4 | DRD4 | Human | Dopamine | A | pKi | 5.08 | 5.08 | 5.08 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.29 | 8.29 | 8.29 | Drug Central |
| MT1 | MTR1A | Human | Melatonin | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| MT2 | MTR1B | Human | Melatonin | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 9.0 | 9.45 | 9.9 | Guide to Pharmacology |
| α1A | ADA1A | Human | Adrenoceptors | A | pKd | 9.1 | 9.1 | 9.1 | Guide to Pharmacology |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 9.5 | 9.5 | 9.5 | Guide to Pharmacology |
| α1A | ADA1A | Rabbit | Adrenoceptors | A | pKd | 8.3 | 8.3 | 8.3 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 9.03 | 9.46 | 9.9 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.98 | 9.56 | 10.15 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKd | 8.6 | 9.0 | 9.81 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.73 | 9.4 | 10.4 | ChEMBL |
| α1A | Q9TSW7 | Pig | Adrenoceptors | A | pKi | 9.2 | 9.33 | 9.6 | PDSP Ki database |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.98 | 7.98 | 7.98 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.99 | 7.99 | 7.99 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.7 | 9.3 | 9.9 | Guide to Pharmacology |
| α1B | ADA1B | Human | Adrenoceptors | A | pKd | 9.1 | 9.1 | 9.1 | Guide to Pharmacology |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 9.08 | 9.08 | 9.08 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.53 | 9.59 | 10.0 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKd | 8.99 | 9.0 | 9.01 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.1 | 9.33 | 9.68 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 9.21 | 9.72 | 10.22 | PDSP Ki database |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 9.25 | 9.25 | 9.25 | PDSP Ki database |
| α1B | A0A4X1U0M4 | Pig | Adrenoceptors | A | pKi | 9.8 | 9.8 | 9.8 | PDSP Ki database |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.0 | 8.0 | 8.0 | Drug Central |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 9.1 | 9.18 | 10.2 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 9.34 | 9.55 | 9.77 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 9.16 | 9.74 | 10.22 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.3 | 5.9 | 6.5 | Guide to Pharmacology |
| α2A | ADA2A | Pig | Adrenoceptors | A | pKi | 5.39 | 5.39 | 5.39 | ChEMBL |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 6.97 | 6.97 | 6.97 | ChEMBL |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 5.78 | 5.78 | 5.78 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.67 | 6.12 | 6.68 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.65 | 6.16 | 6.52 | PDSP Ki database |
| α2A | ADA2A | Pig | Adrenoceptors | A | pKi | 5.94 | 5.94 | 5.94 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α2A | ADA2A | Pig | Adrenoceptors | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.2 | 6.85 | 7.5 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.44 | 7.07 | 7.89 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.94 | 7.4 | 7.84 | PDSP Ki database |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 7.94 | 8.11 | 8.27 | PDSP Ki database |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.5 | 7.25 | 8.0 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.02 | 7.22 | 7.62 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.24 | 7.7 | 7.97 | PDSP Ki database |
| α2C | ADA2C | North American opossum | Adrenoceptors | A | pKi | 7.44 | 7.44 | 7.44 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| μ | OPRM | Rat | Opioid | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
Showing 1 to 71 of 71 entries
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
GTP
| Uniprot
| Species
| Family
| Class
| Type
| Min | Avg | Max | Database
|
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 5.38 | 5.38 | 5.38 | ChEMBL |
| A3 | AA3R | Human | Adenosine | A | pIC50 | 8.04 | 8.04 | 8.04 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 4.96 | 4.96 | 4.96 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 8.3 | 8.3 | 8.3 | Drug Central |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 4.55 | 4.7 | 4.85 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 9.16 | 9.47 | 9.66 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 9.07 | 9.53 | 9.75 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 9.06 | 9.12 | 9.18 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 5.58 | 5.58 | 5.58 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 6.54 | 6.54 | 6.54 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.19 | 6.19 | 6.19 | ChEMBL |
Showing 1 to 11 of 11 entries