promazine


SMILES CN(CCCN1c2ccccc2Sc2c1cccc2)C
InChIKey ZGUGWUXLJSTTMA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 284.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 6.52 6.52 6.52 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 8.34 8.34 8.34 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.43 8.43 8.43 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.21 8.21 8.21 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 8.07 8.07 8.07 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.34 7.34 7.34 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.43 7.43 7.43 ChEMBL
H2 HRH2 Human Histamine A pKi 5.55 5.55 5.55 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.38 7.38 7.38 ChEMBL
H1 HRH1 Human Histamine A pKi 9.4 9.4 9.4 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.06 7.06 7.06 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.53 5.53 5.53 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.9 6.9 6.9 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.91 5.91 5.91 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.66 6.66 6.66 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.41 6.41 6.41 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.28 7.28 7.28 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.93 6.93 6.93 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.16 7.16 7.16 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.78 6.78 6.78 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.89 6.89 6.89 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.52 6.7 6.8 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.38 8.59 8.7 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 7.52 7.59 7.66 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.15 5.15 5.15 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 7.14 7.14 7.15 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.8 6.8 6.8 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 8.62 8.62 8.62 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.19 8.19 8.19 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
D1 DRD1 Human Dopamine A pKi 8.23 8.23 8.23 Drug Central
D2 DRD2 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
D3 DRD3 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
H1 HRH1 Human Histamine A pKi 8.06 8.06 8.06 Drug Central
H2 HRH2 Human Histamine A pKi 8.26 8.26 8.26 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pIC50 5.9 5.9 5.9 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 8.09 8.09 8.09 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.03 8.03 8.03 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.65 5.8 5.95 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.89 7.89 7.89 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 7.75 7.75 7.75 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 7.19 7.19 7.19 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.6 6.6 6.6 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.54 5.54 5.54 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 6.52 6.52 6.52 ChEMBL
H1 HRH1 Human Histamine A pIC50 5.61 7.04 8.46 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.38 6.38 6.38 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.29 5.29 5.29 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.47 6.47 6.47 ChEMBL
D1 DRD1 Human Dopamine A pIC50 5.61 5.61 5.61 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 6.56 6.56 6.56 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.46 6.46 6.46 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.96 5.96 5.96 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.0 7.0 7.0 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 6.31 6.31 6.31 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.69 6.69 6.69 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.64 7.64 7.64 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.3 6.3 6.3 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.28 8.28 8.28 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.1 8.1 8.1 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 7.4 7.4 7.4 ChEMBL
H1 HRH1 Rat Histamine A pIC50 8.23 8.23 8.23 Drug Central