risperidone
SMILES | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 |
InChIKey | RAPZEAPATHNIPO-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 6 |
Hydrogen bond donors | 0 |
Rotatable bonds | 4 |
Molecular weight (Da) | 410.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 7.6 | 7.6 | 7.6 | ChEMBL |
β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 4.66 | 4.66 | 4.66 | ChEMBL |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.39 | 8.24 | 8.85 | ChEMBL |
D3 | DRD3 | Rat | Dopamine | A | pKi | 7.5 | 7.84 | 8.01 | ChEMBL |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 6.9 | 7.51 | 7.84 | ChEMBL |
5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
D5 | DRD5 | Human | Dopamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
D1 | DRD1 | Rat | Dopamine | A | pKi | 6.6 | 7.1 | 7.66 | ChEMBL |
H1 | HRH1 | Guinea pig | Histamine | A | pKi | 7.33 | 7.55 | 8.1 | ChEMBL |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.89 | 8.78 | 9.4 | ChEMBL |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.0 | 8.45 | 8.86 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 5.84 | 5.84 | 5.84 | ChEMBL |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.0 | 8.69 | 9.4 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pKi | 7.0 | 7.67 | 8.59 | ChEMBL |
D2 | DRD2 | Rat | Dopamine | A | pKi | 7.72 | 8.37 | 8.74 | ChEMBL |
D4 | DRD4 | Human | Dopamine | A | pKi | 7.0 | 7.86 | 8.21 | ChEMBL |
α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.0 | 8.42 | 8.64 | ChEMBL |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.14 | 6.62 | 6.89 | ChEMBL |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.0 | 7.5 | 8.44 | ChEMBL |
D1 | DRD1 | Human | Dopamine | A | pKi | 6.0 | 6.6 | 7.68 | ChEMBL |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 5.7 | 5.97 | 6.65 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.7 | 7.76 | 7.82 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 5.96 | 5.96 | 5.96 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.65 | 8.19 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 5.55 | 5.55 | 5.55 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.0 | 7.84 | 8.17 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 9.0 | 9.43 | 10.0 | ChEMBL |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.93 | 6.61 | 7.68 | ChEMBL |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKd | 6.4 | 6.4 | 6.4 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pKi | 8.0 | 8.46 | 9.36 | ChEMBL |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 5.95 | 6.29 | 6.38 | PDSP Ki database |
D1 | DRD1 | Rat | Dopamine | A | pKi | 5.0 | 6.6 | 7.68 | PDSP Ki database |
5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 8.8 | 8.8 | 8.8 | PDSP Ki database |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.93 | 6.48 | 6.8 | PDSP Ki database |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 5.62 | 5.79 | 6.02 | PDSP Ki database |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.85 | 9.65 | 10.8 | PDSP Ki database |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 9.42 | 9.85 | PDSP Ki database |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.4 | 6.45 | 6.5 | Guide to Pharmacology |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.6 | 6.95 | 7.3 | Guide to Pharmacology |
5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 8.0 | 8.0 | 8.0 | ChEMBL |
5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.14 | 7.28 | 8.01 | PDSP Ki database |
5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 7.8 | 7.9 | 8.0 | Guide to Pharmacology |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.85 | 7.74 | 8.41 | PDSP Ki database |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 5.9 | 5.9 | 5.9 | Guide to Pharmacology |
5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.44 | 5.88 | PDSP Ki database |
5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 5.9 | 5.9 | 5.9 | Guide to Pharmacology |
5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 5.91 | 5.91 | 5.91 | PDSP Ki database |
5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 9.3 | 9.65 | 10.0 | Guide to Pharmacology |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.03 | 8.03 | 8.03 | Drug Central |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.47 | 9.4 | PDSP Ki database |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 6.94 | 7.41 | 7.8 | PDSP Ki database |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.5 | 7.55 | 7.6 | Guide to Pharmacology |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.19 | 7.66 | 8.0 | PDSP Ki database |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 6.69 | 6.7 | 6.71 | PDSP Ki database |
5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.3 | 8.5 | 8.7 | Guide to Pharmacology |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 5.0 | 5.21 | 5.55 | PDSP Ki database |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.0 | 5.16 | 5.43 | PDSP Ki database |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.3 | 8.3 | 8.3 | Drug Central |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 5.0 | 5.18 | 5.54 | PDSP Ki database |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.4 | 8.55 | 8.7 | Guide to Pharmacology |
α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 7.8 | 7.9 | 8.0 | Guide to Pharmacology |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.0 | 8.0 | 8.0 | ChEMBL |
α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.05 | 8.05 | 8.05 | PDSP Ki database |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.31 | 8.31 | 8.31 | ChEMBL |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.3 | 8.3 | 8.3 | PDSP Ki database |
α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
D4 | DRD4 | Human | Dopamine | A | pKi | 7.73 | 8.39 | 9.6 | PDSP Ki database |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.82 | 7.32 | 8.0 | PDSP Ki database |
α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.0 | 6.96 | 7.92 | ChEMBL |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.97 | 7.34 | 8.07 | PDSP Ki database |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.04 | 8.58 | 8.89 | PDSP Ki database |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 5.0 | 5.15 | 5.3 | PDSP Ki database |
β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 5.0 | 5.15 | 5.3 | PDSP Ki database |
β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.8 | 8.24 | 8.8 | PDSP Ki database |
D1 | DRD1 | Human | Dopamine | A | pKi | 6.24 | 6.56 | 7.22 | PDSP Ki database |
D1 | DRD1 | Human | Dopamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
D2 | DRD2 | Human | Dopamine | A | pKi | 9.36 | 9.36 | 9.36 | Guide to Pharmacology |
D2 | DRD2 | Human | Dopamine | A | pKi | 7.57 | 8.61 | 9.52 | PDSP Ki database |
D2 | DRD2 | Human | Dopamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.0 | 7.0 | 7.0 | Guide to Pharmacology |
D3 | DRD3 | Human | Dopamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
D4 | DRD4 | Human | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
D5 | DRD5 | Human | Dopamine | A | pKi | 6.25 | 7.03 | 7.8 | PDSP Ki database |
D5 | DRD5 | Human | Dopamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
H1 | HRH1 | Human | Histamine | A | pKi | 7.6 | 7.7 | 7.8 | Guide to Pharmacology |
H1 | HRH1 | Human | Histamine | A | pKi | 7.48 | 7.81 | 8.29 | PDSP Ki database |
H1 | HRH1 | Human | Histamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
H2 | HRH2 | Human | Histamine | A | pKi | 6.92 | 6.92 | 6.92 | PDSP Ki database |
H2 | HRH2 | Human | Histamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
H4 | HRH4 | Human | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
PAF | PTAFR | Human | Platelet-activating factor | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
EP3 | PE2R3 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
EP4 | PE2R4 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
TP | TA2R | Human | Prostanoid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.5 | 8.5 | 8.5 | Guide to Pharmacology |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.31 | 6.8 | 7.68 | PDSP Ki database |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.2 | 6.4 | Guide to Pharmacology |
5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
D3 | DRD3 | Rat | Dopamine | A | pKi | 7.89 | 8.14 | 8.55 | PDSP Ki database |
D3 | DRD3 | Rat | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
CB1 | CNR1 | Rat | Cannabinoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
δ | OPRD | Mouse | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
μ | OPRM | Rat | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.97 | 8.97 | 8.97 | ChEMBL |
α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
CCK2 | GASR | Rat | Cholecystokinin | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.02 | 7.52 | 8.19 | PDSP Ki database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.59 | 8.59 | 8.59 | PDSP Ki database |
H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
H1 | HRH1 | Rat | Histamine | A | pKi | 6.8 | 6.89 | 7.06 | PDSP Ki database |
D1 | DRD1 | Rat | Dopamine | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.4 | 5.62 | 5.88 | PDSP Ki database |
5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 9.4 | 9.4 | 9.4 | PDSP Ki database |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKd | 8.9 | 8.95 | 9.0 | Guide to Pharmacology |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.3 | 8.76 | 9.03 | PDSP Ki database |
5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
κ | OPRK | Guinea pig | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKi | 6.69 | 6.69 | 6.69 | PDSP Ki database |
D4 | DRD4 | Rat | Dopamine | A | pKi | 7.78 | 7.95 | 8.12 | PDSP Ki database |
D2 | DRD2 | Rat | Dopamine | A | pKi | 7.7 | 8.68 | 9.36 | PDSP Ki database |
D2 | DRD2 | Rat | Dopamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
H3 | HRH3 | Guinea pig | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.07 | 5.07 | 5.07 | PDSP Ki database |
β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 8.33 | 8.33 | 8.33 | Drug Central |
5-HT1D | F1MMU1 | Bovine | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.11 | 7.22 | PDSP Ki database |
D2 | A0A287B0Q7 | Pig | Dopamine | A | pKi | 7.43 | 8.29 | 9.08 | PDSP Ki database |
α1B | A0A4X1U0M4 | Pig | Adrenoceptors | A | pKi | 8.5 | 8.5 | 8.5 | PDSP Ki database |
α1A | Q9TSW7 | Pig | Adrenoceptors | A | pKi | 7.8 | 8.67 | 9.3 | PDSP Ki database |
5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.39 | 7.66 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT1A | 5HT1A | Mouse | 5-Hydroxytryptamine | A | pIC50 | 6.37 | 6.37 | 6.37 | ChEMBL |
D2 | DRD2 | Mouse | Dopamine | A | pIC50 | 7.64 | 7.64 | 7.64 | ChEMBL |
α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 9.01 | 9.01 | 9.01 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 4.75 | 4.83 | 4.9 | ChEMBL |
α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 8.02 | 8.02 | 8.02 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pIC50 | 5.83 | 5.83 | 5.83 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pIC50 | 6.06 | 6.5 | 7.6 | ChEMBL |
D2 | DRD2 | Rat | Dopamine | A | pIC50 | 7.43 | 7.63 | 8.4 | ChEMBL |
α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 7.96 | 7.98 | 8.0 | ChEMBL |
5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 6.02 | 6.06 | 6.1 | ChEMBL |
α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 8.01 | 8.01 | 8.01 | ChEMBL |
D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.32 | 6.32 | 6.32 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 7.64 | 7.64 | 7.64 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 7.82 | 8.39 | 8.74 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pIC50 | 7.62 | 7.62 | 7.62 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 8.33 | 9.02 | 9.46 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pIC50 | 7.7 | 7.93 | 8.15 | ChEMBL |
α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 8.0 | 8.0 | 8.0 | ChEMBL |
α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.58 | 7.58 | 7.58 | ChEMBL |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.1 | 5.1 | 5.1 | ChEMBL |
α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 8.71 | 8.71 | 8.71 | ChEMBL |
D2 | DRD2 | Mouse | Dopamine | A | pIC50 | 8.12 | 8.12 | 8.12 | Drug Central |
5-HT1A | 5HT1A | Mouse | 5-Hydroxytryptamine | A | pIC50 | 8.2 | 8.2 | 8.2 | Drug Central |
H1 | HRH1 | Rat | Histamine | A | pIC50 | 7.1 | 7.1 | 7.1 | ChEMBL |
H1 | HRH1 | Rat | Histamine | A | pIC50 | 8.15 | 8.15 | 8.15 | Drug Central |