Biased Signaling Atlas

risperidone

Agent/drug
Bioactivity

risperidone

SMILES	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2
InChIKey	RAPZEAPATHNIPO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	410.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6A93 6CM4
Ligand site mutations	5-HT_2A D₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.89	8.78	9.40	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.00	8.42	8.64	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	7.80	8.67	9.30	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.40	8.55	8.70	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.80	7.90	8.00	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.97	8.97	8.97	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.00	8.00	8.00	ChEMBL
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	8.50	8.50	8.50	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.40	7.40	7.40	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.31	8.31	8.31	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.30	7.30	7.30	Guide to Pharmacology
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	7.60	7.60	7.60	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.00	7.50	8.44	ChEMBL

Showing 1 to 20 of 158 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	9.01	9.01	9.01	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	7.96	7.98	8.00	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.71	8.71	8.71	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.00	8.00	8.00	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.01	8.01	8.01	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.58	7.58	7.58	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	8.02	8.02	8.02	ChEMBL
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	6.37	6.37	6.37	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.02	6.06	6.10	ChEMBL
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	8.20	8.20	8.20	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.33	9.02	9.46	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.64	7.64	7.64	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.82	8.39	8.74	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.32	6.32	6.32	ChEMBL
D₂	DRD2	Mouse	Dopamine	A	pIC50	7.64	7.64	7.64	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	7.43	7.63	8.40	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	7.70	7.93	8.15	ChEMBL
D₂	DRD2	Mouse	Dopamine	A	pIC50	8.12	8.12	8.12	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	7.62	7.62	7.62	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	7.10	7.10	7.10	ChEMBL

Showing 1 to 20 of 25 entries

risperidone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 9

Phase II 15

Phase III 31

Phase IV 21

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6A93 6CM4
Ligand site mutations	5-HT_2A D₂

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Aggressive behaviour	4	MB23.0	N05A	0.599
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Anxiety	3	MB24.3	N05A	0.575
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language	3	6A02.0	N05A	0.451
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	4	6A02.Z	N05A	0.462
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	N05A	0.460
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Conduct-dissocial disorder, unspecified	3	6C91.Z	N05A	0.530
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Dementia due to cerebrovascular disease	3	6D81	N05A	0.352
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Dementia, unknown or unspecified cause	3	6D8Z	N05A	0.575
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	3	6A7Z	N05A	0.607
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Disorders of intellectual development, unspecified	3	6A00.Z	N05A	0.360
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	1	8A01.10	N05A	0.275
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Neurodevelopmental disorders, unspecified	3	6A0Z	N05A	0.259
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Obsessive-compulsive disorder, unspecified	2	6B20.Z	N05A	0.561
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Post traumatic stress disorder	2	6B40	N05A	0.585
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Rett syndrome	3	LD90.4	N05A	0.259
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.606
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.620
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizotypal disorder	1	6A22	N05A	0.037

Showing 1 to 20 of 72 entries

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Main reference

risperidone

risperidone

Chemical Properties

Database connections

Bioactivities

risperidone

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information