Biased Signaling Atlas

ropinirole

Agent/drug
Bioactivity

ropinirole

SMILES	CCCN(CCC)CCc1cccc2c1CC(O)=N2
InChIKey	UHSKFQJFRQCDBE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	260.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.73	5.73	5.73	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.12	6.12	6.12	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.92	5.92	5.92	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.77	5.77	5.77	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.86	5.86	5.86	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.42	5.42	5.42	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.27	8.27	8.27	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 48 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	6.85	6.85	6.85	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.16	8.16	8.16	Drug Central
D₂	DRD2	Bovine	Dopamine	A	pIC50	5.17	5.17	5.17	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.74	5.74	5.74	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	7.12	7.12	7.12	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	6.48	6.87	8.19	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	8.29	8.29	8.29	Drug Central
D₃	DRD3	Rat	Dopamine	A	pIC50	6.97	6.97	6.97	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	7.72	8.03	8.40	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.75	4.80	4.85	ChEMBL

Showing 1 to 10 of 10 entries

ropinirole

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 3

Phase II 12

Phase III 0

Phase IV 6

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Chronic widespread pain	2	MG30.01	N04B	0.517
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	N04B	0.470
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Hyperprolactinaemia	1	5A60.1	N04B	0.567
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	4	8A00.0Z	N04B	0.621
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Progressive myoclonic epilepsy	2	8A61.41	N04B	0.074
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Restless legs syndrome	4	7A80	N04B	0.600
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Stroke not known if ischaemic or haemorrhagic	2	8B20	N04B	0.093
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Chronic widespread pain	2	MG30.01	N04B	0.103
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	N04B	0.304
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Hyperprolactinaemia	1	5A60.1	N04B	0.552
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	4	8A00.0Z	N04B	0.612
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Progressive myoclonic epilepsy	2	8A61.41	N04B	0.074
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Restless legs syndrome	4	7A80	N04B	0.600
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Stroke not known if ischaemic or haemorrhagic	2	8B20	N04B	0.514
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Chronic widespread pain	2	MG30.01	N04B	0.102
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	N04B	0.292
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Hyperprolactinaemia	1	5A60.1	N04B	0.552
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	4	8A00.0Z	N04B	0.609
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Progressive myoclonic epilepsy	2	8A61.41	N04B	0.074
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	A	Restless legs syndrome	4	7A80	N04B	0.599

Showing 1 to 20 of 21 entries

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ropinirole

ropinirole

Chemical Properties

Database connections

Bioactivities

ropinirole

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information