sotalol


SMILES CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C
InChIKey ZBMZVLHSJCTVON-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 272.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations β1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pKi 6.08 6.08 6.08 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 6.1 6.1 6.1 Guide to Pharmacology
β2 ADRB2 Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.36 5.72 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 6.53 6.53 6.53 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 6.3 6.4 6.5 Guide to Pharmacology
β2 ADRB2 Bovine Adrenoceptors A pKd 8.2 8.2 8.2 Drug Central
β2 ADRB2 Bovine Adrenoceptors A pKd 6.24 6.24 6.24 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 6.47 6.47 6.47 PDSP Ki database
β1 ADRB1 Rat Adrenoceptors A pKi 5.65 5.65 5.65 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β2 ADRB2 Dog Adrenoceptors A pIC50 5.28 5.29 5.3 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 5.05 5.25 5.84 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 6.36 6.36 6.36 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pIC50 8.28 8.28 8.28 Drug Central