sertindole


SMILES Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O
InChIKey GZKLJWGUPQBVJQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 440.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.4 6.5 6.6 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.2 9.3 9.4 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 9.0 9.1 9.2 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.04 8.48 8.92 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.0 8.4 8.8 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 7.8 8.43 9.07 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 6.9 6.9 6.9 Guide to Pharmacology
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.48 9.48 9.48 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 9.43 9.43 9.43 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 9.29 9.29 9.29 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 9.18 9.18 9.18 ChEMBL
D1 DRD1 Rat Dopamine A pKi 7.92 7.92 7.92 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.25 7.25 7.25 ChEMBL
H1 HRH1 Human Histamine A pKi 6.24 7.76 9.29 ChEMBL
D2 DRD2 Rat Dopamine A pKi 9.35 9.35 9.35 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.68 7.82 7.96 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.89 9.2 9.7 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.09 8.34 8.59 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.07 9.14 9.22 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.48 7.48 7.48 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.13 8.94 9.35 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.04 8.49 9.21 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.55 8.42 9.07 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.22 9.45 9.85 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 9.07 9.34 9.7 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 8.09 8.49 8.8 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.55 7.55 7.55 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.13 9.06 9.42 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 8.89 8.89 8.89 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.3 6.76 7.22 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.02 7.51 7.8 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 4.93 5.36 6.37 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.44 6.44 6.44 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 6.24 6.24 6.24 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.19 6.19 6.19 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.35 6.35 6.35 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.3 5.3 5.3 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 7.92 8.35 8.8 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.49 6.76 6.89 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.66 5.66 5.66 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.62 8.95 9.29 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 6.36 6.36 6.36 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.55 7.55 7.55 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.98 6.43 6.63 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.22 8.69 9.05 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 8.0 8.0 8.0 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.57 5.57 5.57 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.74 8.74 8.74 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.52 7.54 7.55 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.35 6.35 6.35 PDSP Ki database
PAF PTAFR Human Platelet-activating factor A pKi 6.0 6.0 6.0 PDSP Ki database
TP TA2R Human Prostanoid A pKi 6.0 6.0 6.0 PDSP Ki database
δ OPRD Mouse Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
CCK2 GASR Rat Cholecystokinin A pKi 6.0 6.0 6.0 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.27 8.39 8.64 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.2 6.2 6.2 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.85 8.85 8.85 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.29 6.29 6.29 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.25 8.25 8.25 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
D1 DRD1 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
D3 DRD3 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D4 DRD4 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
H1 HRH1 Human Histamine A pKi 8.03 8.03 8.03 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.03 8.03 8.03 Drug Central
D2 DRD2 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.01 8.01 8.01 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.1 8.1 8.1 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.02 8.02 8.02 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.03 8.03 8.03 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.57 5.57 5.57 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.01 8.01 8.01 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 5.3 5.3 5.3 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.68 6.68 6.68 ChEMBL
μ OPRM Rat Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.68 7.3 7.92 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Rat Adrenoceptors A pIC50 8.47 8.47 8.47 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 8.39 8.39 8.39 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.07 8.07 8.07 Drug Central