spiramide


SMILES Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
InChIKey FJUKDAZEABGEIH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Mouse Dopamine A pKi 5.6 5.6 5.6 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.52 8.52 8.52 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.37 5.37 5.37 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 9.5 9.5 9.5 ChEMBL