terazosin


SMILES COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
InChIKey VCKUSRYTPJJLNI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 387.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1A α1B

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 7.9 8.3 8.7 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.0 8.3 8.6 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.7 8.4 9.1 Guide to Pharmacology
α2B ADA2B Rat Adrenoceptors A pKi 8.11 8.11 8.11 ChEMBL
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.16 9.16 9.16 ChEMBL
α1A ADA1A Rabbit Adrenoceptors A pKd 7.7 7.7 7.7 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 7.58 8.09 8.6 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKd 8.65 8.74 8.83 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 7.46 8.31 9.0 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 8.59 8.6 8.6 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 8.48 8.6 8.72 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 7.52 8.59 8.92 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 7.9 7.98 8.04 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.02 8.51 9.09 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.08 8.52 9.07 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.38 7.04 7.58 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.06 6.65 7.11 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.4 8.24 8.7 ChEMBL
α1A ADA1A Human Adrenoceptors A pKd 7.44 7.44 7.44 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.29 5.81 6.26 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.7 8.82 8.94 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.2 8.71 9.18 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 8.22 8.22 8.22 ChEMBL
α1B ADA1B Human Adrenoceptors A pEC50 8.76 9.03 9.3 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.62 7.62 7.62 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 7.77 7.77 7.77 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.37 6.37 6.37 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 5.22 5.22 5.22 ChEMBL
α1A ADA1A Human Adrenoceptors A pEC50 7.29 7.29 7.29 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 4.86 4.86 4.86 ChEMBL