thioridazine


SMILES CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1
InChIKey KLBQZWRITKRQQV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 370.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.4 7.7 8.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.2 7.25 7.3 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 7.7 7.7 7.7 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 8.59 8.59 8.59 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.69 8.69 8.69 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.54 8.54 8.54 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.76 6.76 6.76 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.6 7.6 7.6 ChEMBL
H2 HRH2 Human Histamine A pKi 6.03 6.03 6.03 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.74 6.95 7.16 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.96 7.96 7.96 ChEMBL
H1 HRH1 Human Histamine A pKi 8.07 8.07 8.07 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.72 7.72 7.72 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.29 6.29 6.29 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.47 7.47 7.47 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.3 7.3 7.3 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.01 7.01 7.01 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.15 7.32 7.48 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.09 7.09 7.09 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.42 7.42 7.42 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.64 7.64 7.64 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.77 8.77 8.77 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.47 8.47 8.47 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.08 7.99 8.9 ChEMBL
κ OPRK Human Opioid A pKi 6.0 6.0 6.0 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.57 7.86 8.1 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.22 7.93 8.96 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.68 8.36 9.15 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.18 8.19 8.2 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.15 7.18 7.2 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 7.92 8.11 8.41 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 7.17 8.15 9.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.07 7.15 7.28 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.26 6.84 7.13 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.34 6.69 6.87 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 6.59 6.59 6.59 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.57 8.31 9.4 PDSP Ki database
D2 A0A287B0Q7 Pig Dopamine A pKi 7.68 7.96 8.18 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.59 8.21 8.82 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.66 7.76 7.85 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 6.92 7.44 7.7 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 7.23 7.46 7.68 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.22 7.28 7.34 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.74 6.02 7.12 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 7.8 7.83 7.85 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 6.52 6.59 6.67 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 7.0 7.03 7.05 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 7.28 8.01 8.64 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.48 8.2 8.57 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.08 7.34 7.85 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.04 7.38 8.05 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.89 7.9 7.92 PDSP Ki database
α1B A0A4X1U0M4 Pig Adrenoceptors A pKi 7.8 7.8 7.8 PDSP Ki database
α1A Q9TSW7 Pig Adrenoceptors A pKi 6.4 7.37 7.9 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.13 8.59 8.82 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.69 6.8 6.97 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.24 6.24 6.24 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.71 6.71 6.71 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.44 6.44 6.44 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.24 7.24 7.24 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.37 7.6 7.82 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.3 8.6 8.89 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.47 6.47 6.47 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
H4 HRH4 Human Histamine A pKi 5.62 5.62 5.62 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
H3 HRH3 Guinea pig Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 7.61 7.61 7.61 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 7.47 7.47 7.47 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.09 8.09 8.09 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.19 8.19 8.19 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
D4 DRD4 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
D5 DRD5 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
H1 HRH1 Human Histamine A pKi 8.11 8.11 8.11 Drug Central
H2 HRH2 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
H4 HRH4 Human Histamine A pKi 8.25 8.25 8.25 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
H2 HRH2 Human Histamine A pKi 6.87 6.87 6.87 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 8.62 8.62 8.62 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pIC50 7.0 7.0 7.0 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 5.89 6.92 7.76 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 8.33 8.33 8.33 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.29 8.29 8.29 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.23 8.23 8.23 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.42 6.42 6.42 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 8.03 8.03 8.03 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.77 6.77 6.77 ChEMBL
H2 HRH2 Human Histamine A pIC50 6.02 6.02 6.02 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 7.1 7.1 7.1 ChEMBL
H1 HRH1 Human Histamine A pIC50 7.14 7.14 7.14 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 7.05 7.05 7.05 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 7.22 7.85 8.55 ChEMBL
D4 DRD4 Human Dopamine A pIC50 5.83 5.83 5.83 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.22 7.22 7.22 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.88 6.88 6.88 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.71 6.71 6.71 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.15 7.15 7.15 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.89 6.89 6.89 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.97 6.97 6.97 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.36 7.36 7.36 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.15 8.15 8.15 ChEMBL
D3 DRD3 Human Dopamine A pIC50 8.01 8.01 8.01 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.36 8.36 8.36 ChEMBL
κ OPRK Human Opioid A pIC50 5.6 5.6 5.6 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.46 7.46 7.46 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.1 8.1 8.1 Drug Central
α1A ADA1A Human Adrenoceptors A pIC50 8.1 8.1 8.1 Drug Central
D1 DRD1 Human Dopamine A pIC50 8.15 8.15 8.15 Drug Central
D3 DRD3 Human Dopamine A pIC50 8.14 8.14 8.14 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.08 8.08 8.08 Drug Central
H1 HRH1 Rat Histamine A pIC50 8.15 8.15 8.15 Drug Central
D1 DRD1 Rat Dopamine A pIC50 8.11 8.11 8.11 Drug Central
D2 DRD2 Human Dopamine A pIC50 8.13 8.13 8.13 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 8.07 8.07 8.07 Drug Central