Biased Signaling Atlas

timolol

Agent/drug
Bioactivity

timolol

SMILES	CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
InChIKey	BLJRIMJGRPQVNF-JTQLQIEISA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	316.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6PS1 6PS6 3D4S
Ligand site mutations	β₁

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.30	8.65	9.00	Guide to Pharmacology
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	6.20	7.62	8.50	ChEMBL
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	9.44	9.44	9.44	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.22	8.44	8.82	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	8.03	8.03	8.03	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	9.70	9.70	9.70	Guide to Pharmacology
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	9.62	9.67	9.78	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.73	9.37	9.70	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.01	8.01	8.01	Drug Central
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	8.01	8.01	8.01	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	6.47	6.47	6.47	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.81	6.01	6.21	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.28	5.28	5.28	ChEMBL

Showing 1 to 18 of 18 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pIC50	8.59	8.59	8.59	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	9.54	9.61	9.67	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	6.34	6.34	6.34	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.57	5.57	5.57	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.30	5.30	5.30	ChEMBL

Showing 1 to 5 of 5 entries

timolol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 2

Phase II 8

Phase III 4

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	6PS1 6PS6 3D4S
Ligand site mutations	β₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anterior ischemic optic neuropathy	9C40.40	S01E, C07A, C07D, C07B	0.046	1	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	S01E, C07A, C07D, C07B	0.698	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E, C07A, C07D, C07B	0.605	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hereditary haemorrhagic telangiectasia	LA90.00	S01E, C07A, C07D, C07B	0.285	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	S01E, C07A, C07D, C07B	0.606	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neoplastic haemangioma, unspecified site	2E81.0Z	S01E, C07A, C07D, C07B	0.584	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ocular hypertension	9C61.01	S01E, C07A, C07D, C07B	0.603	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Oesophageal varices, unspecified	DA26.0Z	S01E, C07A, C07D, C07B	0.522	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified glaucoma or glaucoma suspect	9C6Y	S01E, C07A, C07D, C07B	0.606	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Unspecified injury to unspecified part of trunk, limb or body region	ND56.Z	S01E, C07A, C07D, C07B	0.484	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Venous leg ulcer, unspecified	BD74.3Z	S01E, C07A, C07D, C07B	0.074	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anterior ischemic optic neuropathy	9C40.40	S01E, C07A, C07D, C07B	0.046	1	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	S01E, C07A, C07D, C07B	0.594	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E, C07A, C07D, C07B	0.607	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hereditary haemorrhagic telangiectasia	LA90.00	S01E, C07A, C07D, C07B	0.285	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	S01E, C07A, C07D, C07B	0.609	2	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neoplastic haemangioma, unspecified site	2E81.0Z	S01E, C07A, C07D, C07B	0.584	3	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ocular hypertension	9C61.01	S01E, C07A, C07D, C07B	0.602	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Oesophageal varices, unspecified	DA26.0Z	S01E, C07A, C07D, C07B	0.522	3	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified glaucoma or glaucoma suspect	9C6Y	S01E, C07A, C07D, C07B	0.609	4	Yes

Showing 1 to 20 of 22 entries

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timolol

timolol

Chemical Properties

Database connections

Bioactivities

timolol

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information