Biased Signaling Atlas

tramadol

Agent/drug
Bioactivity

tramadol

SMILES	COc1cccc(C2(O)CCCCC2CN(C)C)c1
InChIKey	TVYLLZQTGLZFBW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	263.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	8.03	8.03	8.03	Guide to Pharmacology
δ	OPRD	Human	Opioid	A	pKi	8.03	8.03	8.03	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	7.85	7.85	7.85	Guide to Pharmacology
κ	OPRK	Human	Opioid	A	pKi	7.85	7.85	7.85	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	5.80	5.80	5.80	Guide to Pharmacology
μ	OPRM	Human	Opioid	A	pKi	5.70	5.75	5.80	ChEMBL
μ	OPRM	Rat	Opioid	A	pKi	5.62	5.62	5.62	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Human	Opioid	A	pIC50	5.12	5.12	5.12	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	5.89	5.89	5.89	ChEMBL

Showing 1 to 2 of 2 entries

tramadol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 5

Phase III 35

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic pain, unspecified	MG30.Z	N02A	0.037	4	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Chronic widespread pain	MG30.01	N02A	0.001	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Low back pain, unspecified	ME84.2Z	N02A	0.259	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N02A	0.074	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Opioid dependence, unspecified	6C43.2Z	N02A	0.002	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Other specified disorders of teeth and supporting structures	DA0A.Y	N02A	0.259	3	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Pain, unspecified	MG3Z	N02A	0.575	4	Yes
AA1R	A₁ receptor	Adenosine receptors	Nucleotide receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N02A	0.037	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic pain, unspecified	MG30.Z	N02A	0.529	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N02A	0.092	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Low back pain, unspecified	ME84.2Z	N02A	0.468	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N02A	0.374	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Opioid dependence, unspecified	6C43.2Z	N02A	0.417	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	N02A	0.605	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N02A	0.583	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Withdrawal due to unknown or unspecified psychoactive substance, unspecified	6C4G.4Z	N02A	0.503	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic pain, unspecified	MG30.Z	N02A	0.529	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N02A	0.092	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Low back pain, unspecified	ME84.2Z	N02A	0.468	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N02A	0.374	3	Yes

Showing 1 to 20 of 42 entries

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tramadol

tramadol

Chemical Properties

Database connections

Bioactivities

tramadol

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information