trifluoperazine
| SMILES | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F |
| InChIKey | ZEWQUBUPAILYHI-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 407.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.9 | 7.9 | 7.9 | Guide to Pharmacology |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.89 | 8.96 | 9.02 | Guide to Pharmacology |
| D4 | DRD4 | Human | Dopamine | A | pKi | 7.36 | 7.36 | 7.36 | Guide to Pharmacology |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 8.66 | 8.66 | 8.66 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pKd | 9.27 | 9.27 | 9.27 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.39 | 6.39 | 6.39 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 6.87 | 7.81 | 8.13 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 7.62 | 8.08 | 8.4 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 7.18 | 7.18 | 7.18 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.1 | 7.1 | 7.1 | PDSP Ki database |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.77 | 6.85 | 6.93 | PDSP Ki database |
| D4 | DRD4 | Rat | Dopamine | A | pKi | 7.72 | 7.72 | 7.72 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 9.7 | 9.71 | 9.72 | PDSP Ki database |
| 5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.42 | 5.84 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.17 | 8.75 | 9.02 | PDSP Ki database |
| D4 | DRD4 | Human | Dopamine | A | pKi | 7.36 | 7.4 | 7.49 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 6.42 | 6.71 | 7.0 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.2 | 7.2 | 7.21 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 6.74 | 6.74 | 6.74 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.42 | 6.42 | 6.42 | PDSP Ki database |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 6.13 | 6.13 | 6.13 | PDSP Ki database |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 8.68 | 8.68 | 8.68 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 9.02 | 9.22 | 9.35 | PDSP Ki database |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.62 | 7.62 | 7.62 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 4.92 | 5.47 | 6.02 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.18 | 6.18 | 6.18 | PDSP Ki database |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.79 | 6.79 | 6.79 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.41 | 6.41 | 6.41 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.54 | 6.54 | 6.54 | PDSP Ki database |
| D2 | DRD2 | Dog | Dopamine | A | pKi | 8.92 | 8.92 | 8.92 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 5.89 | 5.89 | 5.89 | PDSP Ki database |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.66 | 5.66 | 5.66 | PDSP Ki database |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.03 | 8.03 | 8.03 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pKd | 8.03 | 8.03 | 8.03 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 5.0 | 5.0 | 5.0 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 4.6 | 4.7 | 4.9 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.5 | 4.5 | 4.5 | ChEMBL |