volinanserin


SMILES COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O
InChIKey HXTGXYRHXAGCFP-OAQYLSRUSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 373.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.5 7.43 7.89 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.82 9.44 10.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKd 9.85 9.85 9.85 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.65 5.83 5.89 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.99 6.38 6.58 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.73 9.45 10.52 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.35 7.27 8.42 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.5 7.6 7.7 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.3 5.46 5.62 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 6.37 6.37 6.37 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 5.92 6.4 6.89 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.72 5.72 5.72 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.57 6.57 6.57 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 5.84 5.84 5.84 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.28 5.67 6.2 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.23 5.65 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.0 5.42 6.27 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.18 7.18 7.18 PDSP Ki database
H4 HRH4 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
δ OPRD Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
κ OPRK Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
μ OPRM Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
V2 V2R Human Vasopressin and oxytocin A pKi 5.0 5.0 5.0 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 5.0 5.06 5.17 PDSP Ki database
CB1 CNR1 Rat Cannabinoid A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.87 7.0 7.06 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.32 8.32 8.32 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.5 7.9 9.3 Guide to Pharmacology