Biased Signaling Atlas

amisulpride

Agent/drug
Bioactivity

amisulpride

SMILES	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC
InChIKey	NTJOBXMMWNYJFB-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	369.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	5.15	5.15	5.15	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.95	5.95	5.95	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.81	5.81	5.81	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.50	6.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.22	5.45	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	PDSP Ki database

Showing 1 to 20 of 69 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pIC50	8.52	8.52	8.52	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 2 of 2 entries

amisulpride

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 3

Phase III 0

Phase IV 4

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	2	6A60.Z	N05A	0.660
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Nausea or vomiting	4	MD90	N05A	0.573
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.732
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	2	6A60.Z	N05A	0.597
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Nausea or vomiting	4	MD90	N05A	0.540
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.704

Showing 1 to 6 of 6 entries