AMLODIPINE


SMILES CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
InChIKey HTIQEAQVCYTUBX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 408.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pKi 5.1 5.1 5.1 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 5.27 5.27 5.27 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.58 6.58 6.58 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.63 5.63 5.63 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.65 6.65 6.65 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.87 5.87 5.87 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.25 8.25 8.25 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.29 8.29 8.29 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2C ADA2C Human Adrenoceptors A pIC50 5.75 5.75 5.75 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.22 6.22 6.22 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.54 5.54 5.54 ChEMBL