Biased Signaling Atlas

apraclonidine

Agent/drug
Bioactivity

apraclonidine

SMILES	Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1
InChIKey	IEJXVRYNEISIKR-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	1
Molecular weight (Da)	244.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_2A β₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.50	8.50	8.50	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.54	8.54	8.54	ChEMBL
α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	6.54	6.54	6.54	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.53	7.94	8.35	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	8.32	8.32	8.32	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.52	7.52	7.52	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.67	7.67	7.67	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.52	7.52	7.52	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.55	4.55	4.55	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 2 of 2 entries

apraclonidine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 4

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_2A β₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Blepharoptosis, unspecified	9A03.0Z	S01E	0.542	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E	0.541	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Blepharoptosis, unspecified	9A03.0Z	S01E	0.526	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E	0.597	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Blepharoptosis, unspecified	9A03.0Z	S01E	0.526	2	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E	0.597	4	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Blepharoptosis, unspecified	9A03.0Z	S01E	0.526	2	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E	0.597	4	Yes

Showing 1 to 8 of 8 entries