apraclonidine


SMILES Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1
InChIKey IEJXVRYNEISIKR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 244.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α2A β2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 8.5 8.5 8.5 Guide to Pharmacology
α2B ADA2B Rat Adrenoceptors A pKi 8.32 8.32 8.32 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.53 7.94 8.35 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 6.54 6.54 6.54 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.67 7.67 7.67 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.54 8.54 8.54 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.52 7.52 7.52 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.52 7.52 7.52 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.55 4.55 4.55 ChEMBL