ABAPERIDONE


SMILES O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12
InChIKey ICAXEUYZCLRXKY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 452.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pKi 6.62 6.62 6.62 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 8.62 8.62 8.62 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.92 7.92 7.92 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.75 6.75 6.75 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.03 7.03 7.03 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.27 8.27 8.27 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 7.77 7.77 7.77 ChEMBL