HYDROXYCHLOROQUINE


SMILES CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChIKey XXSMGPRMXLTPCZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 335.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1D ADA1D Human Adrenoceptors A pKi 5.63 5.63 5.63 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 4.14 4.14 4.14 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 4.7 4.7 4.7 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 4.8 4.8 4.8 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.26 5.26 5.26 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.32 5.32 5.32 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.19 5.19 5.19 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.29 5.63 5.98 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 4.81 4.81 4.81 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.32 8.32 8.32 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.22 8.22 8.22 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.27 8.27 8.27 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.38 8.38 8.38 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.33 8.33 8.33 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.25 8.25 8.25 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.32 8.32 8.32 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.28 8.28 8.28 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1D ADA1D Human Adrenoceptors A pIC50 5.32 5.32 5.32 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.53 5.53 5.53 ChEMBL