CHEMBL1644980
SMILES | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 |
InChIKey | SGUZNMAAJVIZHU-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 1 |
Rotatable bonds | 7 |
Molecular weight (Da) | 487.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 6.43 | 6.43 | 6.43 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 5.67 | 5.67 | 5.67 | ChEMBL |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.32 | 6.32 | 6.32 | ChEMBL |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.2 | 6.2 | 6.2 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 5.77 | 5.77 | 5.77 | ChEMBL |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.49 | 6.49 | 6.49 | ChEMBL |
D1 | DRD1 | Human | Dopamine | A | pKi | 6.87 | 6.87 | 6.87 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pKi | 7.42 | 7.42 | 7.42 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.21 | 7.21 | 7.21 | ChEMBL |
D4 | DRD4 | Human | Dopamine | A | pKi | 7.24 | 7.24 | 7.24 | ChEMBL |
D5 | DRD5 | Human | Dopamine | A | pKi | 6.92 | 6.92 | 6.92 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 6.56 | 6.56 | 6.56 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 5.82 | 5.82 | 5.82 | ChEMBL |
κ | OPRK | Human | Opioid | A | pKi | 5.88 | 5.88 | 5.88 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 7.16 | 7.16 | 7.16 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |