(-)-noradrenaline [5823]



(-)-noradrenaline


SMILES NC[C@H](O)c1ccc(O)c(O)c1
InChIKey SFLSHLFXELFNJZ-QMMMGPOBSA-N

Chemical Properties

Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 2
Log P 0.090
Molecular weight (Da) 169.1
Stereochemistry info full

Database connections

Structure pdb 7YMH 7BU6 7EJ0 9CHU
Model (RFAA) α1D α2A α1B α2B β2 β1 α1A α2C β3 D1
Model (Boltz2) β2 α2A β1 α1B α1D α1A α2C α2B β3
Ligand site mutations α1A α1B α2A α2B β2 β3 D4
GPCRdb related ligands

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

(-)-noradrenaline


Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Distribution across phases (no. indications)

Phase I 9
Phase II 18
Phase III 27
Phase IV 36

Database connections

Structure pdb 7YMH 7BU6 7EJ0 9CHU
Model (RFAA) α1D α2A α1B α2B β2 β1 α1A α2C β3 D1
Model (Boltz2) β2 α2A β1 α1B α1D α1A α2C α2B β3
Ligand site mutations α1A α1B α2A α2B β2 β3 D4
GPCRdb related ligands

Sankey plot

Drug Information

Target Disease
Gene Protein Receptor family Ligand type Class Name Phase ICD11 ATC Association score