AMPEROZIDE


SMILES CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey NNAIYOXJNVGUOM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 401.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.17 7.17 7.17 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.26 6.26 6.26 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.9 6.07 6.36 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.7 7.81 7.92 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.3 6.57 6.85 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.59 6.59 6.59 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.51 5.51 5.51 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 6.14 6.14 6.14 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.75 4.75 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.4 5.4 5.4 ChEMBL