CHEMBL160932


SMILES Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1
InChIKey MFGYZKGJWDJWAA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 365.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Bovine Dopamine A pKi 4.96 4.96 4.96 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.64 8.64 8.64 ChEMBL
D3 DRD3 Human Dopamine A pKi 4.68 4.68 4.68 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.23 4.24 4.24 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.35 5.35 5.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pEC50 7.92 7.92 7.92 ChEMBL