CHEMBL1632217


SMILES Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1
InChIKey QIJPXEALWJLAOE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 452.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.9 8.9 8.9 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 9.7 9.7 9.7 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.1 7.1 7.1 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.3 9.3 9.3 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.7 6.7 6.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database