CHEMBL1644980


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
InChIKey SGUZNMAAJVIZHU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 487.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 6.92 6.92 6.92 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.49 6.49 6.49 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.24 7.24 7.24 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.87 6.87 6.87 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.77 5.77 5.77 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.43 6.43 6.43 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.67 5.67 5.67 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.21 7.21 7.21 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.32 6.32 6.32 ChEMBL
δ OPRD Human Opioid A pKi 5.82 5.82 5.82 ChEMBL
κ OPRK Human Opioid A pKi 5.88 5.88 5.88 ChEMBL
μ OPRM Human Opioid A pKi 7.16 7.16 7.16 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.42 7.42 7.42 ChEMBL
H2 HRH2 Human Histamine A pKi 6.56 6.56 6.56 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database