2-MPP


SMILES COc1ccccc1N1CCNCC1
InChIKey VNZLQLYBRIOLFZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 192.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.6 6.75 6.9 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.61 6.76 6.9 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.55 7.23 8.02 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.92 8.92 8.92 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.51 5.51 5.51 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.61 6.76 6.9 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.39 5.65 6.17 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.65 5.65 5.65 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.88 6.88 6.88 PDSP Ki database
α1A ADA1A Rat Adrenoceptors A pKi 5.46 5.46 5.46 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.87 6.87 6.87 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 7.76 7.76 7.76 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.92 5.92 5.92 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pIC50 5.7 5.7 5.7 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pIC50 4.47 4.47 4.47 ChEMBL