3-quinuclidinyl-benzilate


SMILES O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2
InChIKey HGMITUYOCPPQLE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 337.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations A2A M1 M2 M3 M4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 10.4 10.4 10.4 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKd 9.7 10.1 10.5 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKd 10.4 10.4 10.4 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKd 10.22 10.46 10.7 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 10.52 10.54 10.57 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 10.06 10.08 10.1 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 10.19 10.28 10.37 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 10.43 10.45 10.47 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 10.36 10.41 10.46 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 10.29 10.29 10.29 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKd 10.6 10.7 10.8 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 10.35 10.35 10.35 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 10.1 10.35 10.6 Guide to Pharmacology
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 9.3 9.3 9.3 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 9.74 9.74 9.74 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database