A-794282


SMILES CCc1ccc(cc1)n1cnc2c(c1=O)sc1c2c(ccn1)N(C)C
InChIKey VCUKKMIXURRDKL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 350.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.71 6.71 6.71 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.3 8.3 8.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.52 8.52 8.52 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.33 8.33 8.33 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.52 8.52 8.52 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.36 6.36 6.36 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 5.88 5.88 5.88 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.3 8.45 8.52 ChEMBL