BRL 37344


SMILES C[C@H](Cc1ccc(cc1)OCC(=O)O)NC[C@@H](c1cccc(c1)Cl)O
InChIKey ZGGNJJJYUVRADP-ACJLOTCBSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 9
Molecular weight (Da) 363.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β3 ADRB3 Human Adrenoceptors A pKi 6.4 6.7 7.0 Guide to Pharmacology
β3 ADRB3 Mouse Adrenoceptors A pKi 6.5 6.5 6.5 Guide to Pharmacology
β3 ADRB3 Rat Adrenoceptors A pKi 6.5 6.5 6.5 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKi 6.02 6.07 6.18 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 5.54 5.98 6.2 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 4.95 5.45 5.95 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β2 ADRB2 Rat Adrenoceptors A pIC50 5.89 7.32 8.04 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pIC50 5.48 6.1 6.72 ChEMBL
β3 ADRB3 Human Adrenoceptors A pEC50 6.17 7.7 10.02 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 6.54 6.92 7.3 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 5.52 5.52 5.52 ChEMBL
β1 ADRB1 Human Adrenoceptors A pEC50 5.77 5.77 5.77 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 5.3 5.3 5.3 ChEMBL
β3 ADRB3 Rat Adrenoceptors A pEC50 8.08 8.37 8.66 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pIC50 8.04 8.04 8.04 ChEMBL