CHEMBL184995


SMILES Cc1nc(C#Cc2ccc(-c3ccccc3)nc2)cs1
InChIKey OUYHNXKLIHUODF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 276.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 8.7 8.7 8.7 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.26 8.26 8.26 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.92 8.92 8.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 9.3 9.3 9.3 ChEMBL