AZD6538


SMILES N#Cc1ccc(nc1)c1noc(n1)c1cc(F)cc(c1)C#N
InChIKey PBVKGEMPZBKZOA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 291.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.55 7.55 7.55 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.55 7.65 7.75 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.87 7.87 7.87 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.29 7.58 7.87 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.84 8.16 8.49 ChEMBL