CHEMBL189118


SMILES Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12
InChIKey RVSLLQIPFFIMSB-KPKJPENVSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 472.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 6.1 6.1 6.1 ChEMBL
H2 HRH2 Human Histamine A pIC50 6.07 6.07 6.07 ChEMBL
MCH1 MCHR1 Human Melanin-concentrating hormone A pIC50 6.84 7.58 7.8 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.05 6.05 6.05 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.32 6.32 6.32 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.05 6.05 6.05 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.89 5.89 5.89 ChEMBL
D3 DRD3 Human Dopamine A pIC50 5.64 5.64 5.64 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 5.72 5.72 5.72 ChEMBL