compound 10 [PMID: 15482908]


SMILES N#Cc1cc(F)cc(c1)n1nnc(n1)c1[nH]cc(n1)C
InChIKey BKGULEDZLIMLMY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 269.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.72 7.72 7.72 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.72 7.72 7.72 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.11 7.11 7.11 Guide to Pharmacology