compound 23i [PMID: 17929793]


SMILES C[C@@H]1CNc2c(O1)cnc1c2c2ncn(c(=O)c2s1)c1ccc(cc1)Cl
InChIKey LFUPTQIEOBBAJE-SECBINFHSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 384.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 9.7 9.7 9.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.85 8.85 8.85 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.85 8.85 8.85 ChEMBL