Biased Signaling Atlas

candesartan

Agent/drug
Bioactivity

candesartan

SMILES	CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
InChIKey	HTQMVQVXFRQIKW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	440.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank DrugBank Guide To Pharmacology PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.76	5.76	5.76	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.50	5.50	5.50	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	6.16	6.16	6.16	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKd	10.29	10.29	10.29	Guide to Pharmacology
AT₁	AGTRA	Rat	Angiotensin	A	pKd	8.00	8.25	8.50	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	7.98	8.22	8.46	ChEMBL
AT₁	AGTR1	Rabbit	Angiotensin	A	pKi	9.19	9.19	9.19	ChEMBL

Showing 1 to 7 of 7 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.42	5.42	5.42	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.37	5.37	5.37	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	5.91	5.91	5.91	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	9.49	9.61	9.72	Guide to Pharmacology
AT₁	AGTR1	Human	Angiotensin	A	pIC50	6.96	8.03	9.16	ChEMBL
AT₁	AGTR1	Rabbit	Angiotensin	A	pIC50	7.55	7.55	7.55	ChEMBL
AT₁	AGTR1	Bovine	Angiotensin	A	pIC50	6.96	6.96	6.96	ChEMBL
BLT₂	LT4R2	Human	Leukotriene	A	pEC50	4.82	4.82	4.82	ChEMBL

Showing 1 to 8 of 8 entries

candesartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 2

Phase II 7

Phase III 11

Phase IV 2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank DrugBank Guide To Pharmacology PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Alcoholic liver disease, unspecified	2	DB94.Z	C09C, C09D	0.038
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Atrial fibrillation, unspecified	3	BC81.3Z	C09C, C09D	0.587
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Bipolar type I disorder, unspecified	1	6A60.Z	C09C, C09D	0.019
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	COVID-19	3	RA01	C09C, C09D	0.554
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Cardiomegaly	3	BC45	C09C, C09D	0.358
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Chronic hepatitis C	2	1E51.1	C09C, C09D	0.166
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Cocaine dependence, unspecified	2	6C45.2Z	C09C, C09D	0.037
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Congenital supravalvar aortic stenosis	3	LA8A.3	C09C, C09D	0.463
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Congestive heart failure	3	BD10	C09C, C09D	0.599
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Diabetic retinopathy, unspecified	3	9B71.0Z	C09C, C09D	0.019
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Dilated cardiomyopathy, unspecified	3	BC43.0Z	C09C, C09D	0.503
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Diseases of the myocardium or cardiac chambers, unspecified	3	BC4Z	C09C, C09D	0.325
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Essential hypertension, unspecified	4	BA00.Z	C09C, C09D	0.708
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Heart failure, unspecified	3	BD1Z	C09C, C09D	0.611
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Hypertrophic cardiomyopathy, unspecified	2	BC43.1Z	C09C, C09D	0.132
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Migraine with aura, unspecified	3	8A80.1Z	C09C, C09D	0.074
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Migraine without aura	3	8A80.0	C09C, C09D	0.074
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Migraine, unspecified	2	8A80.Z	C09C, C09D	0.075
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Polyneuropathy, unspecified	2	8C0Z	C09C, C09D	0.052
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	1	6C46.2Z	C09C, C09D	0.037

Showing 1 to 20 of 21 entries

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Main reference

candesartan

candesartan

Chemical Properties

Database connections

Bioactivities

candesartan

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information