compound 3 [PMID: 21105727]


SMILES O/N=C\1/c2ccccc2OC2(C1C2)C(=O)Nc1ccc(cc1)C
InChIKey VKCTUZKPBYSTDW-SILNSSARSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 308.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.22 6.22 6.22 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.22 6.22 6.22 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 5.82 5.82 5.82 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.1 5.1 5.1 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.05 5.05 5.05 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 5.82 5.82 5.82 ChEMBL