carazolol


SMILES OC(COc1cccc2c1c1ccccc1[nH]2)CNC(C)C
InChIKey BQXQGZPYHWWCEB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 298.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 6PS0

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pKd 9.7 9.95 10.2 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKi 8.4 8.4 8.4 Guide to Pharmacology
β3 ADRB3 Mouse Adrenoceptors A pKi 7.7 7.7 7.7 Guide to Pharmacology
β3 ADRB3 Rat Adrenoceptors A pKi 7.7 7.7 7.7 Guide to Pharmacology
β1 ADRB1 Mouse Adrenoceptors A pKi 10.05 10.05 10.05 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 9.94 9.94 9.94 PDSP Ki database
β3 ADRB3 Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
β3 ADRB3 Mouse Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
β3 ADRB3 Rat Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 9.94 10.23 10.52 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 9.9 10.2 10.5 Guide to Pharmacology
β1 ADRB1 Mouse Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β3 ADRB3 Human Adrenoceptors A pEC50 8.8 8.8 8.8 Guide to Pharmacology