CDPPB


SMILES N#Cc1cccc(c1)C(=O)Nc1cc(nn1c1ccccc1)c1ccccc1
InChIKey BKUIZWILNWHFHD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 364.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 8TAO 8T6J
Ligand site mutations mGlu5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 6.6 6.6 6.6 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.42 5.42 5.42 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 7.6 7.8 8.0 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 7.7 7.7 7.7 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 6.75 7.27 8.0 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 7.01 7.27 7.7 ChEMBL